Parkinsonism & related disordersLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Parkinson DiseaseHumansAnimals
Protective or Pathogenic? Kinase activity and the neurodevelopmental origins of G2019S LRRK2-Associated Parkinson's disease.
Emilia M Gatto, Alberto J Espay, Melisa Espindola, Gustavo Da Prat, Marcelo A Kauffman
Published: 202610.1016/j.parkreldis.2025.108133
Abstract
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common monogenic cause of Parkinson's disease (PD), with the p.Gly2019Ser (G2019S) variant being particularly prevalent. The LRRK2 gene encodes a large, multi-domain protein (LRR…
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