Obesity research & clinical practiceAnimalsMaleMicePyroptosisDiet
Ectopic fat deposition in intestinal wall caused the increase of L cell pyroptosis mainly through local hypoxia.
Yimeng Liu, Huihui Wu, Qianwen Ma, Zhijin Lu, Pu Zhao, Xiaoyu Li, Meiyan Li, Jie Wen
Published: 202510.1016/j.orcp.2025.12.002
Abstract
PURPOSE: L-cell dysfunction occurs in people with obesity, characterized by alterations in glucagon-like peptide-1 (GLP-1) secretion.The mechanism of L-cell dysfunction in obesity is not clear. This study was to reveal the mechanisms of GLP-1 secreti…
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