Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Regulatory T cells attenuate astrogliosis via IL-10/STAT3/PKC/vimentin signaling and promote neurological recovery after spinal cord injury.
Ying Li, Yi Xie, Rui Liu, Hao Huang, Ziyue Wang, Xuantong Liu, Zhiyuan Yu, Minghuan Wang, Wei Wang, Xiang Luo
Published: 202510.1016/j.neurot.2025.e00827
Abstract
Spinal cord injury (SCI) triggers reactive astrogliosis, leading to the formation of an astrocyte scar around the lesion. Regulatory T cells (Tregs), a subset of immune cells, infiltrate the peri-lesional area through the compromised blood-spinal cor…
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