Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Validation in Drosophila of the in silico predicted clomipramine as repurposable for SOD1-ALS.
Francesco Liguori, Susanna Amadio, Chiara Angioli, Angelo Ferriero, Iolanda Passaro, Francesca Alberti, Fiammetta Vernì, Cinzia Volonté
Published: 202510.1016/j.neurot.2025.e00793
Abstract
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive motor neuron degeneration and muscle weakness, generally leading to death due to respiratory failure within 2-5 years of symptom onset. Curren…
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