Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Restoration neurite growth by removing the blockage of endosome trafficking in Alzheimer-like mice.
Huimin Zhao, Fangjie Li, Sheng Xu, Yanan Du, Peipei Chen, Jie Wei, Kun Hao, Xiaoquan Liu, Haochen Liu
Published: 202510.1016/j.neurot.2025.e00777
Abstract
Synaptic loss is strongly associated with cognitive decline in Alzheimer's disease (AD). Endosomal trafficking dysfunction, observed in AD brains, impairs neurite growth. Because endosomal trafficking is essential for synaptic development, we selecte…
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