Neuroscience
Altered cerebral thyroid hormone, WNT and NOTCH signalling and impaired myelination following intrauterine growth restriction in rats.
Aminath Azhan, Angela L Cumberland, Ginevra Chincarini, Mikaela Barresi, Nadia Hale, David H Rowitch, Flora Wong, David W Walker, Mary Tolcos
Published: 202510.1016/j.neuroscience.2025.12.068
Abstract
Intrauterine growth restriction (IUGR) is associated with impaired brain development, including hypomyelination. Preclinical studies suggest that reduced myelination in IUGR may result from delayed oligodendrocyte maturation, but the mechanisms remai…
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