NeuroscienceAnimalsToll-Like Receptor 4MaleDiabetes MellitusExperimental
TLR4 deletion reduces small fiber sensory abnormalities and nerve degeneration in diabetic male mice.
Sarah Crowards, Janelle Ryals, Lana Heslop, Will Hauser, Gentry Totta-Griese, Trent Madden, Douglas E Wright
Published: 202510.1016/j.neuroscience.2025.10.052
Abstract
Diabetic peripheral neuropathy (DPN) is a prevalent complication of diabetes, significantly impairing quality of life and lacking effective disease-modifying treatments. Chronic inflammation involving toll-like receptor 4 (TLR4) has been implicated i…
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