NeuroscienceAnimalsNF-kappa BCellular SenescenceSignal TransductionPresbycusis
LCN2 promotes HEI-OC1 cells senescence via activating NF-κB signal pathway in presbycusis.
Jingjing Wu, Xiaowen Liu, Daxue Zhu, Baicheng Xu, Yufen Guo
Published: 202510.1016/j.neuroscience.2025.10.018
Abstract
Presbycusis, or age-related hearing loss (ARHL), is a prevalent sensory disorder in the elderly, driven by genetic factors, oxidative stress, inflammation responses, and cellular senescence. Despite its significance, the molecular mechanisms underlyi…
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