NeurosciencePhosphorylationHumansC9orf72 Proteintau ProteinsCell Death
C9orf72 related poly-Glycine-Alanine promotes tau phosphorylation and cell death via ERK1/2 interaction in cellular models.
Jiahan Zhuang, Zixuan Zhang, Hongfu Jin, Ji Qi, Yuanyuan Chen, Lin Ding, Chenglai Fu, Weiwei Cheng
Published: 202510.1016/j.neuroscience.2025.09.053
Abstract
Frontotemporal lobar degeneration (FTLD), particularly cases linked to the C9ORF72 GGGGCC repeat expansion (r(G4C2)exp), is closely associated with TAR DNA-binding protein 43 (TDP-43) pathology but also exhibits concurrent tau pathology characterized…
Preview only. Read the full abstract at the source