NeuropharmacologyAnimalsDentate GyrusMaleNeuronal PlasticityRats
GABAB receptor blockade in the dentate gyrus restores glutamatergic synaptic plasticity and hippocampus dependent memory in an AD-like rat model.
Jianzhou Chen, Yuening Tian, Linping Wang, Zihan Zhang, Qinghua Jin, Bin Xiao
Published: 202610.1016/j.neuropharm.2025.110789
Abstract
Synaptic dysfunction driven by glutamate-mediated excitotoxicity is a hallmark of hippocampus-dependent memory impairment in Alzheimer's disease (AD). Although GABAergic signaling is known to regulate excitatory/inhibitory (E/I) balance, the precise…
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