NeuropharmacologyAnimalsalpha7 Nicotinic Acetylcholine ReceptorLevodopaDyskinesiaDrug-Induced
Inhibition of levodopa-induced abnormal involuntary movements (AIMs) using a selective α7 nicotinic positive allosteric modulator.
Yasaman Malekizadeh, Kiana Hassankhani, Alice E Kingslake, Lucy E Annett, Mohammed Shoaib, Mahmoud M Iravani
Published: 202610.1016/j.neuropharm.2025.110786
Abstract
Chronic administration of nicotine and nicotinic ligands have been shown to reduce levodopa-induced dyskinesia (LID) in rodents and primates. Due to its unique extra-striatal localisation and biochemical signalling properties, the α7 subtype of nicot…
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