NeuropharmacologyAnimalsHypoxia-IschemiaBrainCaffeineNewborn
Caffeine Citrate does not reduce brain injury following inflammation-amplified hypoxia ischaemia or hypoxia ischaemia in the Newborn Piglet Model.
George Maple, Christopher Meehan, Ilenia d'Angelo, Yujin Kim, Ellie Campbell, Katie Tucker, Kennosuke Tsuda, Louise Han, Georgina Norris, Alison Mintoft, Francisco Torrealdea, Alan Bainbridge, John Barks, Raymand Pang, Nicola J Robertson
Published: 202610.1016/j.neuropharm.2025.110763
Abstract
There is a need to develop alternative therapies for neonatal encephalopathy (NE) in term babies. Caffeine citrate exposure saw benefit in preclinical models of hypoxia-ischaemia (HI). We assessed the safety and cytoprotective efficacy of caffeine ci…
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