Gut microbiota-mediated amino acid reprogramming in ketamine-induced neurotoxicity: A novel microbiota-amino acid-mitochondrial axis associated with cognitive deficits.

Ketamine, a noncompetitive N-methyl-D-aspartate receptor antagonist, is associated with chronic abuse leading to schizophrenia-like cognitive deficits. The gut-brain axis may play a role in mediating substance-induced neurotoxicity; however, its invo…

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