NeuropharmacologyAnimalsPyroptosisNLR FamilyPyrin Domain-Containing 3 ProteinMice
5-Lipoxygenase triggers depressive-like behaviors via activating NLRP3-induced pyroptosis in CUMS-exposed mice.
Yani Zhang, Zheng Yang, Ting Xu, Qian Wang, Tingting Sang, Xuan Sheng, Yan Fang, Lisheng Chu
Published: 202610.1016/j.neuropharm.2025.110704
Abstract
5-Lipoxygenase (5-LOX) is implicated the pathogenesis of depression, yet the underlying molecular mechanism remains unclear. In our study, we investigated the dynamic changes of 5-LOX expression after chronic unpredictable mild stress (CUMS) stimulat…
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