NeuropharmacologyAnimalsHypothalamo-Hypophyseal SystemMalePituitary-Adrenal SystemMice
Genetic deletion of NAPE-PLD alters stress responsiveness and HPA-axis functionality in a context-dependent manner in mice.
Taylor J Woodward, Diana Dimen, Emily Fender Sizemore, Sarah Stockman, Fezaan Kazi, Serge Luquet, Ken Mackie, Istvan Katona, Andrea G Hohmann
Published: 202510.1016/j.neuropharm.2025.110702
Abstract
The endocannabinoid (eCB) system regulates stress responsiveness and hypothalamic-pituitary-adrenal (HPA) axis activity. The enzyme N-acyl phosphatidylethanolamine phospholipase-D (NAPE-PLD) is primarily responsible for the synthesis of the endocanna…
Preview only. Read the full abstract at the source