Neuron
Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptopathy in encephalitis.
Ghazal Shammas, Margot Piccinno, Kristof Egervari, Sylvain Lemeille, Alexandre Mariotte, Federica Maltese, Alessandra Panzeri, Ingrid Wagner, Nicolas Fonta, Tiphaine Furlan, Mario Kreutzfeldt, Ilena Vincenti, Alexander Yermanos, Nicolas Page, Camilla Bellone
Published: 202510.1016/j.neuron.2025.11.006
Abstract
In infectious and autoimmune disorders of the central nervous system, neurons can become cognate immunological targets of cytotoxic T cells, leading to persistent functional and synaptic impairments. However, the molecular underpinnings of such irrev…
Preview only. Read the full abstract at the source