Neuron
Elevated calneuron-1, an accessory subunit of muscarinic receptors, induces frontotemporal dysconnectivity and schizophrenia-like deficits.
Anja M Oelschlegel, Jastyn A Pöpplau, Alexandre Ryzynski, Johannes Hradsky, Pasham Parameshwar Reddy, Gemma Navarro, Irene Reyes-Resina, PingAn Yuanxiang, Liudmila Sosulina, Hiroshi Kaneko, Giriraj Sahu, Anne Günther, Maria Andres-Alonso, Jeffrey Lopez-Rojas, Ahmed A A Aly
Published: 202510.1016/j.neuron.2025.10.038
Abstract
Calneuron-1 is a Ca2+ sensor that has been linked in several genome-wide association studies to schizophrenia (SCZ). We show that calneuron-1 expression is elevated in the dorsolateral prefrontal cortex of SCZ patients and that overexpression in the…
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