NeuroImage
Excess iron in deep gray matter is associated with cognitive and functional decline: The mediating role of white matter myelin.
Jonghyun Bae, Angelique De Rouen, Zhaoyuan Gong, Nathan Zhang, Noam Y Fox, Murat Bilgel, Christopher M Bergeron, Luigi Ferrucci, Mustapha Bouhrara
Published: 202610.1016/j.neuroimage.2026.121730
Abstract
BACKGROUND: Cerebral iron accumulation is a hallmark of aging and age-related neurodegenerative conditions. This study explored whether higher iron levels in deep gray matter (DGM) structures contribute to motor and cognitive decline and whether this…
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