Neurobiology of agingAnimalsDisease ModelsAnimalProgranulinsMicroglia
Lysophosphatidic acid derivative is a novel candidate of therapeutic agents for a mouse model of frontotemporal dementia with progranulin deficiency.
Nami Yamamoto, Rino Takei, Mari Gotoh, Yasunori Miyamoto, Kei Hashimoto
Published: 202610.1016/j.neurobiolaging.2025.11.006
Abstract
Frontotemporal dementia (FTD) is driven by progranulin haploinsufficiency, in which age-dependent microglial activation promotes neurodegeneration through TDP-43 proteinopathy. Cyclic phosphatidic acid (cPA) is a natural phospholipid mediator charact…
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