Neurotoxicology
Targeting glutamate receptors with IEM-1925: A strategy against soman-induced status epilepticus and neurodegeneration.
Yuxin Lin, Qian Jin, Yuanqing Chen, Jingyan Wang, Yi Zhang, Manzhu Cao, Jingjing Shi, Liqin Li
Published: 202610.1016/j.neuro.2026.103389
Abstract
Exposure to organophosphorus nerve agents (OPNAs) like soman frequently develops status epilepticus (SE), leading to brain damage. Existing antiseizure medications (e.g., diazepam, DZP) often demonstrate insufficient efficacy. To develop more effecti…
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