NeurotoxicologyAnimalsMethotrexateBrainMiceAntimetabolites
The "route cause" of methotrexate-induced brain structure changes in a juvenile mouse model: Comparison of systemic and CNS-targeted chemotherapy.
Sun Eui Choi, Tiffany Ayoub, Gail Lee, Anne L Wheeler, Sharon L Guger, Rosanna Weksberg, Shinya Ito, Russell J Schachar, Johann Hitzler, Brian J Nieman
Published: 202610.1016/j.neuro.2025.103363
Abstract
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and while five-year survival rates exceed 90 %, survivors display neurocognitive deficits. Magnetic resonance imaging (MRI) measurements indicate smaller volume across the brain i…
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