Neuroscience research
A novel brainstem-targeted G51D α-synuclein fibril-injected mouse model exhibits sequential emergence of sleep and motor dysfunction.
Shinnosuke Yasugaki, Ami Kaneko, Hibiki Okamura, Hideki Hayakawa, Kensuke Ikenaka, Cesar Aguirre, Masashi Yanagisawa, Hideki Mochizuki, Kousuke Baba, Yu Hayashi
Published: 202610.1016/j.neures.2026.105023
Abstract
Abnormal accumulation of alpha-synuclein (α-syn) is a central pathologic hallmark of synucleinopathies such as Parkinson's disease (PD), with rapid eye movement sleep behavior disorder (RBD) widely recognized as a prodromal manifestation of these dis…
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