Neuroscience researchHumansNeurodegenerative DiseasesNeuronsAnimalsInduced Pluripotent Stem Cells
The application of directly induced neurons into neurodegenerative disease modeling.
Keita Matsumoto, Sumihiro Maeda
Published: 202610.1016/j.neures.2025.104993
Abstract
The advent of directly induced neurons (iNs) from human somatic cells has revolutionized disease modeling in neurodegeneration. This approach bypasses pluripotent stage during the neuronal cell inducing steps and preserves donor age-related signature…
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