Neuroscience researchtau ProteinsHumansAlzheimer DiseaseScatteringSmall Angle
Hindering tau fibrillization by disrupting transient precursor clusters.
Tomomi Takahashi, Takashi Nonaka, Reiko Ohtani, Masato Hasegawa, Yukiko Hori, Taisuke Tomita, Rei Kurita
Published: 202510.1016/j.neures.2025.104968
Abstract
Tau protein, a central player in Alzheimer's disease (AD), exhibits cytotoxicity upon fibril formation. Understanding the early stages of tau fibrillization is therefore critical for the development of effective therapeutics. Previous work [Rasmussen. e…
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