Neuroscience letters
L17E cell-penetrating peptide enhances intranasal delivery of IgG to the cerebrospinal fluid in mice.
Naoya Hashikawa, Taiki Terado, Takuya Noda, Riyo Kashimoto, Takumi Iima, Masamune Oro, Sora Tambara, Narumi Hashikawa-Hobara
Published: 202610.1016/j.neulet.2026.138521
Abstract
Antibody-based therapeutics are promising for treating central nervous system (CNS) diseases; however, brain delivery is severely restricted by the blood-brain barrier (BBB). Intranasal administration has gained attention as a noninvasive route propo…
Preview only. Read the full abstract at the source