Neuroscience lettersDietKetogenicGastrointestinal MicrobiomeAnimalsProto-Oncogene Proteins c-akt
The anti-epileptic mechanism of a ketogenic diet regulating the gut microbiota via SIRT2 activation of the PI3K/AKT signaling pathway.
Minghua Li, Haifeng Deng, Ling Ma, Manli Sun
Published: 202610.1016/j.neulet.2025.138488
Abstract
PURPOSE: Epilepsy (EP) is a disorder caused by sudden abnormal discharges of neurons in the brain. A ketogenic diet (KD) has significant anticonvulsant effects in some epileptic patients, but the signaling pathway remains unclear. This study aims to…
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