Neuroscience lettersAnimalsMethadoneCystinyl AminopeptidaseHippocampusRats
Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures.
Frida Stam, Sara Bjurling, Erik Nylander, Esther Olaniran Håkansson, Johan Gising, Mats Larhed, Luke R Odell, Alfhild Grönbladh, Mathias Hallberg
Published: 202510.1016/j.neulet.2025.138415
Abstract
Insulin-regulated aminopeptidase (IRAP) is emerging as a pharmaceutical target for treatment of neurotoxic- and neurodegenerative symptoms commonly seen in cognitive impairments. Ligands of IRAP, such as Angiotensin IV and similar analogues, bind to…
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