Neurochemistry international
USP53 promotes NOTCH2-induced neuroinflammation in Alzheimer's disease.
Dandan He, Huajian Zhao, Yong Zhu, Yufei Kou, Tao Liu, Huahai Huang, Haiming Yang, Lihua Zhang, Jingyue Deng, Feng Xu, Qingyong Wang
Published: 202510.1016/j.neuint.2025.106109
Abstract
PURPOSE: This study aimed to investigate the role of USP53 and its associated signaling pathway associated with USP53 in Alzheimer's disease (AD). METHODS: In vivo experiments were conducted in C57BL/6, 5XFAD, and USP53-knockout 5XFAD (USP53-/-) mice…
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