Neurochemistry internationalAnimalsAlzheimer DiseaseGlycogen Synthase Kinase 3 betatau ProteinsMice
A novel GSK3β inhibitor ameliorates tau aggregation and neuroinflammation in Alzheimer's disease.
Xin-Yue Ning, Wen-Jie Liu, Li-Jun Zhou, Nan Wang, Xin-Zhu Li, Li-Meng Wu, Zhen-Shu Li, Ai-Zhu Yang, Si-Yuan Liu, Zong-He Xu, Fang-Hua Xun, Zi-Hua Xu, Qing-Chun Zhao
Published: 202610.1016/j.neuint.2025.106090
Abstract
In Alzheimer's disease, increased GSK3β activity drives tau phosphorylation and directly or indirectly triggers neuroinflammation, neuronal damage and cognitive decline. We previously developed a novel GSK3β inhibitor, ZLWH-60, which demonstrated inh…
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