Neurochemistry internationalAnimalsLipocalin-2MiceProto-Oncogene Proteins c-aktAstrocytes
Astrocytic HIF-1α/VEGF induces endothelial PI3K/Akt activation to accelerate post-ischemic angiogenesis upon LCN2 inhibition.
Ning Tian, Xiaoxia Li, Yanlin Jiang, Jungang Deng, Hao Wang, Bing Guo, Meiling Chen, Rujia Liao
Published: 202510.1016/j.neuint.2025.106078
Abstract
Therapeutic angiogenesis represents a pivotal yet underexplored avenue for functional recovery following cerebral ischemia. Although lipocalin-2 (LCN2) participates in neuropathological processes, its cell-type-specific regulation of post-ischemic va…
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