New biotechnology
The GigaAssay: A combined high throughput and highly accurate platform for variant classification.
Christopher J Giacoletto, Liz J Valente, Lancer Brown, Sara Patterson, Rewatee Gokhale, Susan M Mockus, Wayne W Grody, Hong-Wen Deng, Jerome I Rotter, Martin R Schiller
Published: 202510.1016/j.nbt.2025.12.001
Abstract
ERBB2 (HER2) is a critical oncogene, yet the comprehensive and standardized assessment of its variant effects, particularly concerning receptor tyrosine kinase function, remains a major challenge. To compare the oncogenic potential of benchmark varia…
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