Neurobiology of diseaseAnimalsalpha7 Nicotinic Acetylcholine ReceptorAstrocytesMiceTransgenic
Astrocytic α7-nicotinic acetylcholine receptors mediate pain information processing and perception.
Teng Teng, Shaofan Yang, Jin Li, Haoyu Wang, Fengjuan Wu, Yong He, Jihua Fan, Hongwei Shi, Mingzhu Huang, Xiang Zhou, Ying Liu, Mingyue Gong, Chuanyan Yang, Huiquan Wang, Zhenlu Cai
Published: 202610.1016/j.nbd.2025.107245
Abstract
The astrocyte-neuron network in the primary somatosensory cortex (S1) responds dynamically to pain stimuli and plays a pivotal role in pain processing. These stimuli activate astrocytic α7-nicotinic acetylcholine receptors (α7-nAChRs), yet their cont…
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