Neurobiology of diseaseHumansMaleFemaleGlymphatic SystemMachado-Joseph Disease
Diffusion along perivascular spaces as a marker for Glymphatic system impairment in spinocerebellar Ataxia type 3.
Xiao-Yue Xia, Zi-Qiang Huang, Hao-Hang Lin, Zhen-Yi Liu, Lin Zhang, Meng-Cheng Li, Yu-Qin Tu, Na-Ping Chen, Jun Ni, Qun-Lin Chen, Jian-Ping Hu, Shi-Rui Gan, Xin-Yuan Chen
Published: 202610.1016/j.nbd.2025.107232
Abstract
Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder characterized by the accumulation of polyglutamylated ATXN3 protein within neurons, which can potentially compromise the integrity of the brain's glymphatic system. Our objective is…
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