Neurobiology of diseaseHumansMultiple System AtrophyMaleFemaleMiddle Aged
Free-water imaging reveals cholinergic pathway damage in multiple system atrophy.
Yao Wang, Han Zhang, Shan Ren, Xinning Zhang, Sushi Wang, Weizheng Ran, Wenyang Tian, Ying Zhou, Zhigang Chen
Published: 202610.1016/j.nbd.2025.107213
Abstract
BACKGROUND: Dysfunction of the cholinergic system is implicated in the pathophysiology of Multiple System Atrophy (MSA). However, in vivo assessment of cholinergic pathways originating from the nucleus basalis of Meynert (NBM) and pedunculopontine nu…
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