Neurobiology of diseaseAnimalsGlycolysisGlaucomaGTP PhosphohydrolasesEpendymoglial Cells
Lactylated histone H4K8 regulation of MFN2/Wnt signaling integrates glycolytic metabolism and Müller cell activation in the pathogenesis of glaucoma.
Shiyuan Xiao, Yue Li, Jun Wang, Mengran Wang, Bing Bu, Wenmin Jiang
Published: 202510.1016/j.nbd.2025.107178
Abstract
Elevated intraocular pressure (IOP) imposes a substantial glycolytic demand on retinal tissue, driving excessive lactate production to sustain neuronal energy homeostasis. In the present study, we demonstrate that this metabolic stress markedly incre…
Preview only. Read the full abstract at the source