Nanomedicine : nanotechnology, biology, and medicineAnimalsOsteoarthritisMiceProdrugsTissue Distribution
Pharmacokinetic and biodistribution (PK/BD) study of ProGel-Dex, a thermoresponsive dexamethasone prodrug for sustained joint pain relief in a mouse model of osteoarthritis.
Xin Wei, Gang Zhao, Xiaoke Xu, Zhenshan Jia, Devendra Kumar, Evan Glissmeyer, Daniel Tran, Haochen Jiang, Sumbal Talib, Ningrong Chen, Zhulian Wang, Yazen Alnouti, Steven R Goldring, Dong Wang
Published: 202610.1016/j.nano.2025.102885
Abstract
Intraarticular (IA) administration of ProGel-Dex was previously found to provide sustained joint pain relief with excellent safety in arthritis animal models. To explore ProGel-Dex' working mechanisms, we conducted a comprehensive pharmacokinetics/bi…
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