Nanomedicine : nanotechnology, biology, and medicineTriple Negative Breast NeoplasmsGlutathioneHumansGlucoseLiposomes
Dual metabolic targeting liposomes potentiate triple-negative breast cancer radiosensitivity via glucose and glutathione starvation.
Henan Zhang, Yanbin Liu, Xuezhi Gao, Guoli Ji, Yanzhen Zheng, Fei Luo, Xing Qi, Shasha Zhao, Shanghui Guan, Cong Wang, Ming Lu
Published: 202510.1016/j.nano.2025.102870
Abstract
Triple-negative breast cancer (TNBC) frequently develops resistance to radiotherapy, while its metabolic reliance on glucose and glutamine presents new therapeutic targets for radiotherapy sensitization. This study developed a targeted nanoliposome (…
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