Mucosal immunology
Integrated human and mouse single-cell profiling reveals immune-stromal niche driving silicosis.
Christina Begka, Matthew Macowan, Bailey Cardwell, Anh Thu Dang, Carmel P Daunt, Roxanne Chatzis, Hayley Barnes, David Pilcher, Ian Glaspole, Ryan F Hoy, Nicola L Harris, Glen P Westall, Benjamin J Marsland
Published: 202610.1016/j.mucimm.2026.01.003
Abstract
Silicosis is an inflammation-driven pulmonary fibrosis caused by occupational inhalation of silica particles. Macrophages are crucial in silicosis pathology, yet their interaction with stromal cells in orchestrating fibrosis progression remains poorl…
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