Multiple sclerosis and related disorders
Real-world detection of paramagnetic rim lesions and their association with disease burden in multiple sclerosis.
Olavi Misin, Anni Piispanen, Markus Matilainen, Riitta Parkkola, Mikko Nyman, Teija Sainio, Jussi Hirvonen, Laura Airas
Published: 202610.1016/j.msard.2026.107012
Abstract
BACKGROUND: Paramagnetic rim lesions (PRLs) are an emerging MRI biomarker in multiple sclerosis (MS). On susceptibility-sensitive MRI, PRLs are characterized by a paramagnetic shift at the lesion rim corresponding to iron-laden macrophages and microg…
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