Mutation researchUrinary Bladder NeoplasmsGlutaminaseHumansGlutamineAnimals
FOXA2 promotes glutamine metabolism to facilitate the malignant development of bladder cancer by transcriptionally increasing GLS1 expression.
Quan Yuan, Bowen Liu, Wei Yan, Huifeng Li, Jinxian Pu
Published: 202510.1016/j.mrfmmm.2025.111920
Abstract
BACKGROUND: Forkhead box A2 (FOXA2) is found to be abnormally overexpressed in bladder cancer (BCa), but its role and underlying molecular mechanisms in BCa progression remain revealed. METHODS: The expression levels of FOXA2, glutaminase 1 (GLS1), g…
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