Mutation researchCarcinomaNon-Small-Cell LungHumansHypoxia-Inducible Factor 1alpha Subunit
Hypoxia-induced HIF-1α enhanced the tumorigenesis in non-small cell lung cancer by targeting GAB2.
Xunxia Zhu, Xiaoyong Shen, Xiaoyu Chen, Xuelin Zhang, Wen Gao
Published: 202510.1016/j.mrfmmm.2025.111917
Abstract
Non-small cell lung cancer (NSCLC) is a lethal disease with high morbidity and mortality rates. HIF-1α is confirmed to be involved in NSCLC. However, the detailed mechanism of its role remains unclear. NCI-H226 and SK-MES-1 cell lines were used to ex…
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