Molecular metabolism
Impaired hepatic metabolism in Hereditary Fructose Intolerance confers fructose-independent risk for steatosis and hypertriglyceridemia.
Melissa A Fulham, John D Griffin, Sylvie Perez, Zhongyuan Sun, Natalie A Daurio, Gang Xing, Michelle F Clasquin, Melissa R Miller, Craig L Hyde, Scott P Kelly, Magalie Boucher, Rachel Poskanzer, Ramya Gamini, Evanthia Pashos, Ying Zhang
Published: 202510.1016/j.molmet.2025.102310
Abstract
OBJECTIVES: Hereditary fructose intolerance (HFI), caused by Aldolase B deficiency, is a rare genetic disorder where fructose exposure leads to severe metabolic pathologies including Type-2 diabetes and liver steatosis. Despite adhering to fructose-f…
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