Molecular immunologyHumansProto-Oncogene Proteins c-aktApoptosisCell ProliferationPhosphatidylinositol 3-Kinases
Isoimperatorin inhibits cell proliferation and induces apoptosis via regulating PI3K/AKT pathway in acute lymphoblastic leukemia.
Jing Xiao, Yan Wang
Published: 202610.1016/j.molimm.2025.12.009
Abstract
OBJECTIVES: This study aims to explore whether isoimperatorin (ISOIM) regulates the malignant phenotype of T‑cell acute lymphoblastic leukemia (T-ALL) cells through the PI3K/AKT pathway and programmed cell death ligand-1 (PD-L1). METHODS: Through in…
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