Molecular cellHumansDNA Copy Number VariationsLiver NeoplasmsSingle-Cell AnalysisBreast Neoplasms
Delineating the copy-number substructure of metastatic tumors with CopyKit.
Junke Wang, Darlan Conterno Minussi, Alexander Davis, Runmin Wei, Hanghui Ye, Emi Sei, Aislyn Schalck, Yun Yan, Hua-Jun Wu, Shanshan Bai, Cheng Peng, Min Hu, Anna Casasent, Alejandro Contreras, Hui Chen
Published: 202610.1016/j.molcel.2025.12.026
Abstract
Tumors are composed of a myriad of subclones that bulk DNA sequencing (DNA-seq) methods cannot accurately resolve. Single-cell DNA-seq methods were developed to address this issue, yet their data analysis remains challenging. Here, we present CopyKit…
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