Molecular cellMechanistic Target of Rapamycin Complex 1ArginineAnimalsMiceHumans
CASTOR1 and CASTOR2 respond to different arginine levels to regulate mTORC1 activity.
Chan Liu, Yifan Zhang, Yilun Wang, Min Wu, Yunchao Li, Jiashuai Wei, Jiawen Shi, Rong Wang, Li Su, Tingting Yang, Jin Li, Junjie Xiao, Jianping Ding, Tianlong Zhang
Published: 202610.1016/j.molcel.2025.12.016
Abstract
Mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth, responding to amino acid availability. While mTORC1 is modulated by amino acid sensors like CASTOR1, the mechanisms driving its dynamic response to fluctuating…
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