Molecular cellAurora Kinase AHumansAlu ElementsExonsCarcinoma
Finding an Achilles' heel of cancer cells: Exonized Alu elements in AURKA.
Beatrice Zhang, Omar Abdel-Wahab
Published: 202610.1016/j.molcel.2025.12.011
Abstract
In this issue of Molecular Cell, Kral et al.1 identify a targetable, novel mechanism of pancreatic ductal adenocarcinoma (PDAC) tumorigenesis via SRSF1 splicing-mediated regulation of an Alu-derived exon in Aurora kinase A (AURKA).