Molecular cellAnimalsHistonesMiceNucleosomesChromatin
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations.
Sandra Nitsch, Aria E Coraor, Tamas Schauer, Yiheng Wu, Jianfeng Sun, Natalie Möritz, Jonas Funke, Harsh Nagpal, Gabriella N L Chua, Federica Battistini, Shannon M Lauberth, Eva Richard, Modesto Orozco, Shixin Liu, Lourdes R Desviat
Published: 202610.1016/j.molcel.2025.11.030
Abstract
Histone modifications play crucial roles in genome function. However, how chromatin integrates physiological and metabolic responses at the molecular level remains largely unknown. Acetylation of histone H4 lysine 16 (H4K16ac) is unique, as it direct…
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