Molecular cellHumansCellular SenescenceRNA Polymerase IITranscription FactorsRNA Processing
Defective RNA processing and ELOA-mediated transcriptional elongation in reversible cellular senescence suggest aging by transcription.
Saeid Parast, Simai Wang, Marta Iwanaszko, Yue He, Deniz G Olgun, Sarah Gold, Jacob M Zeidner, Yuki Aoi, Benjamin C Howard, William R Thakur, Vijay Ramani, Ali Shilatifard
Published: 202510.1016/j.molcel.2025.11.021
Abstract
We previously established distinct roles for the transcriptional elongation factors PAF1, negative elongation factor (NELF), SPT4/5, and SPT6 using auxin-inducible degron systems in human cell lines. Here, we integrate long- and short-read RNA-seq da…
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