Molecular cellCCCTC-Binding FactorCell Cycle ProteinsCohesinsHumansChromosomal Proteins
Two CTCF motifs impede cohesin-mediated DNA loop extrusion.
Roman Barth, Richard Janissen, Laura Muras, Jaco van der Torre, Gabriele Litos, Eli van der Sluis, Ashmiani van den Berg, Iain F Davidson, Jan-Michael Peters, Cees Dekker
Published: 202510.1016/j.molcel.2025.11.001
Abstract
Human cohesin extrudes DNA into loops and is positioned along the genome by stalling at the human CCCTC-binding factor (CTCF) upon encountering its N-terminal region (NTR). The mechanism underlying this stalling, however, is unresolved. Using single-…
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