Molecular cellHumansRNA HelicasesRNA Polymerase IIMultifunctional EnzymesR-Loop Structures
A role for human senataxin in contending with pausing and backtracking during transcript elongation.
Zhong Han, Shiqing Fu, Jens Vilstrup Johansen, David Lopez Martinez, Jiangman Lou, Thierry Boissière, Dandan He, Daniel Blears, Anouk M Olthof, A Barbara Dirac-Svejstrup, Jesper Q Svejstrup
Published: 202510.1016/j.molcel.2025.10.019
Abstract
Senataxin (SETX) regulates RNA polymerase II (RNAPII) transcription and helps maintain genome stability, at least partly by suppressing R-loops. However, despite its importance in human disease, the precise function of SETX has remained unclear. Empl…
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